Current Issue : July-September Volume : 2021 Issue Number : 3 Articles : 1 Articles
The objective of the present study was to enhance the solubility and dissolution rate of Aripiprazole (APZ) and to prepare orally disintegrating tablet of aripiprazole co-crystals. Various formulations were prepared by direct compression using different concentrations of superdisintegranting agent croscarmellose sodium and sodium starch glycolate. Croscarmellose sodium show good swelling index. Precompression parameters of formulation batches have good flow property. The tablets prepared by direct compression using different concentration of croscarmellose sodium and sodium starch glycolate and croscarmellose sodium show less DT i.e. 22±5 s as compared to sodium starch glycolate. It was found that in-vitro disintegration time decrease with increasing superdisintegrant i.e. Croscarmellose sodium and Sodium Starch Glycolate. Wetting time, Water absorption ratio, % CDR found to be satisfactory. An optimization result shows great impact of compression pressure and superdisintegrant on orally disintegrating tablet. Croscarmellose sodium showed good disintegrant property than Sodium Starch Glycolate in formulating the orally disintegrating tablet. Disintegrated property is depending on compression pressure and concentration of superdisintegrant....
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